CAR-T Cell Therapy approved for Cancer

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The revolutionary cancer treatment known as CAR-T (Chimeric Antigen Receptor-T) cell therapy, created by the IIT-Bombay spin-off ImmunoACT, has received market authorization from the Drug Controller General of India (DCGI). The path for its commercial introduction in India is paved by this authorization.

About CAR-T Cell Therapy

What is it?

  • Chimeric antigen receptor T cell therapy is referred to as CAR-T cell therapy.
  • This kind of cancer immunotherapy makes use of the patient’s own T cells, which have been genetically altered in a lab to improve their capacity to identify and eliminate cancer cells.

How does it work?

  • White blood cells called T cells are in charge of recognizing and combating infection and disease.
  • Antigens are substances or compounds that the immune system recognizes, and each T cell has a receptor capable of identifying them.
  • Antigens present in cancer cells may be recognized by the immune system as normal, so enabling the malignancy to elude the immunological response.
  • In the lab, CAR-T cells are genetically modified to express a novel receptor that binds to cancer cells and kills them.

Therapy Process

The process involves several steps, including:

1. Collecting T Cells: Blood is drawn from the patient’s arm, and T cells are separated from the blood using an apheresis machine.

2. Engineering T Cells: In a laboratory, the T cells are modified by adding a manufactured CAR, and they are allowed to multiply and grow.

3. Infusing CAR-T Cells: Once enough CAR-T cells are prepared, they are injected back into the patient’s arm.

  • Chemotherapy may be recommended before CAR-T cell infusion to enhance treatment effectiveness.
  • The process can take place in an outpatient infusion center or a hospital setting.

Cancers Treated

  • Certain cancers respond well to CAR-T cell therapy, especially when other therapies are failing.
  • At the moment, the FDA has approved it for the treatment of hematological malignancies, such as multiple myeloma, lymphoma, and leukemia.

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